Large Scale Plants 2017-12-29T14:19:30+00:00

3 Large Scale Plants: P3, P8, Hydrogenation Plant

P3

Typical input batch size: 125kg -> 350Kg

Maximum containment: Band 4*

Equipment:

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Seed Tanks x 2

Cone Mill

Tanks x 6

Drum Charging Unit

Wet Mill

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Laminar Air Flow Booth

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P8

Typical input batch size: 125 Kg -> 410 Kg

Maximum containment: Band 3*

Equipment:

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Drum Charging Unit

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Laminar Air Flow Booth

Hydrogenation

Typical input batch size: 125kg

Maximum containment: Band 4*

Equipment:

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Drum Charging Unit

Laminar Air Flow Booth

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Swords Campus Band System

* This Band System is used at the Swords Campus. APIs will be assigned a specific EG (Exposure Guideline) e.g Apixaban is 0.003 mg/m3) therefore band 4

* Intermediates are not assigned an EG, so will instead be placed into a a band & generally controlled to midpoint of band

* The band relates to potency, with band 5 Special Case being the most potent material

* The more potent the material, the more containment required to control the exposure. The engineering in P4/P4A are capable of containing band 5/5 special care

Band CRange MG/M3
1 1.0
2 0.1<1.0
3 0.01<0.1
4 0.001<0.01
5

5 special case

0.001<0.0001
<0.0001

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